Population Pharmacokinetics Of Propranolol in Patients with Liver Cirrhosis
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منابع مشابه
Fleroxacin pharmacokinetics in patients with liver cirrhosis.
In this open-label study, the disposition of fleroxacin in liver disease in 12 healthy male volunteers, 6 male cirrhotics without ascites (group A), and 6 male cirrhotics with ascites (group B) was evaluated. Fleroxacin (400 mg) was administered orally and intravenously to each subject in a random crossover fashion. Fleroxacin was completely absorbed and achieved similar peak concentrations in ...
متن کاملPharmacokinetics of oltipraz in diabetic rats with liver cirrhosis.
BACKGROUND AND PURPOSE The incidence of diabetes mellitus is increased in patients with liver cirrhosis. Oltipraz is currently in trials to treat patients with liver fibrosis and cirrhosis induced by chronic hepatitis types B and C and is primarily metabolized via hepatic cytochrome P450 isozymes CYP1A1/2, 2B1/2, 2C11, 2D1 and 3A1/2 in rats. We have studied the influence of diabetes mellitus on...
متن کاملPatients with Liver Cirrhosis
.. Objective: To determine the frequency and severity of hypoglycemia in patients with liver cirrhosis. Study Design: Cross sectional case series study. Period: Six months. Setting: Liaquat University Hospital Hyderabad. Methods: All the patients of liver cirrhosis, of >12 years of age and of either gender were evaluated for hypoglycemia by assessing the glycemic status through random or fastin...
متن کاملAltered pharmacokinetics of voriconazole in a patient with liver cirrhosis.
Voriconazole (VRC; Vfend [Pfizer, United Kingdom]) is a broad-spectrum triazole with activity against fungi including non-albicans Candida, Aspergillus, Fusarium, and Scedosporium species. Favorable therapeutic responses in patients with plasma VRC levels above 2.05 g/ml were found previously (9). The main adverse effects of VRC are hepatotoxicity and blurred vision (1, 2, 4, 6, 11). Prolonged ...
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ژورنال
عنوان ژورنال: Clinical Therapeutics
سال: 2017
ISSN: 0149-2918
DOI: 10.1016/j.clinthera.2017.05.159